eNewsletter - Education and Research

Free to Breathe Launches New Research Grant Program

Free to Breathe recently launched a new research grant program focused solely on research that prevents or stops lung cancer metastasis. The grant program supports high-impact, innovative lung cancer research within this area of emphasis that will result in clinical translation by the end of the 3-year award period. Proposals from interdisciplinary, collaborative teams, as well as collaboration with industry partners, are encouraged.

For 2015, Free to Breathe expects to provide up to three $600,000 awards, paid over a three-year period.

The details:

  • Research Focus: Stopping or preventing lung cancer metastasis
  • Research Goal: Clinical translation within the 3-year award period
  • Eligibility: Independent investigators at or above the level of Assistant Professor at US based not-for-profit institutions
  • Grant Award: Up to three awards; $600,000 each, paid over a 3-year period.
  • Letter of Intent Deadline: November 7, 2014

Click here for complete eligibility information and application details.

Lengerich Named Interim Associate DirectorGene Lengerich, VMD, MS

Eugene (Gene) Lengerich, V.M.D., M.S., was appointed Interim Associate Director, Population Sciences, effective September 1, 2014. In this new role, Dr. Lengerich will provide oversight to the cancer control and population sciences research program and serve on the leadership team of the Cancer Institute.

Dr. Lengerich currently serves as Professor of Public Health Sciences and Director of the Public Health Preparedness option in the Homeland Security graduate program. Since 2010, he has been Director of the Community Sciences and Health Outcomes (CSHO) Core of Penn State Hershey Cancer Institute. The CSHO Core works with Cancer Institute investigators for community engaged and health disparities research, as well study recruitment and health services research. The Core has been funded by the American Cancer Society for community engaged research in Harrisburg. Dr. Lengerich is also the principal investigator of the Northern Appalachia Cancer Network, which has been funded for studies in cancer prevention and control in rural Pennsylvania.

Clinical Trials Office Welcomes New Team Members

Christina Rodriguez joined the team in the regulatory group this summer. Christina is an invaluable member of our team, opening new studies and helping to keep us in good standing for ongoing projects. She came to us with five years of experience at Penn State Hershey, most recently as a PPAS Precert Associate where some of her responsibilities included insurance verification and participation in patient billing activities. 

Stephanie Wachter and Heather Rutherford are the newest members of our CRC team. Many of you may recognize Stephanie and Heather from their excellent service as staff nurses in the inpatient unit caring for our hematology/oncology patients. Stephanie is a great addition to our team. Heather will be working with our breast group as well as helping with some other areas where extra hands are needed.

Faculty Awards (June - August 2014)

Investigator Research Sponsor
Chandra Belani A Phase II, Multicenter, Single-Arm Study of MPDL3280A in Patients with PD-L1-Positive Locally Advanced or Metastatic NSCLC Genentech, Inc.
David DeGraff Transcriptional Control of Bladder Cancer Tumorigenesis Bladder Cancer Advocacy Network
John Flanagan Nanodiscs as a Vehicle for Rapid Throughput Membrane Protein Characterization PA TSF
William Higgins Multimodal Image-Guided Intervention System for Lung Cancer Diagnosis and Staging NCI
Sang Lee Association Study Between C282Y HFE Mutant, Iron and Cholesterol for Neuroblastoma Treatment Children's Miracle Network
Craig Meyers Nanosonics NanoSonic, Inc.
Robert Paulson Test the Efficacy of Derivatives of D12PG13 in Inducing Apoptosis of Leukemia Stem Cells and Bulk Leukemia Cells Oncomega, Inc.
Jeffrey Pu A 24-week with Possible Extension, Prospective, Multicentre, Randomized, Double Blind, Placebo-controlled, 2-parallel Group with a Randomization 1:1 AB Science
Arun Sharma A Novel Compound for Colorectal Cancer Prevention NCI
Raghu Sinha Pilot Study of Oral Liposomal Glutathione Supplementation on Levels of Glutathione in Blood and Biomarkers of Oxidative Stress and Immune Function in Healthy Adults Researched Nutritionals
Jianxun Song Fundamental Properties of Tissue-associated HSC-Tregs that Relate to Anti-Autoimmunity PA TSF

Faculty Publications (June - August 2014)

  1. Alam, S., Bowser, B. S., Israr, M., Conway, M. J., and Meyers, C. (2014). Adeno-associated virus type 2 infection of nude mouse human breast cancer xenograft induces necrotic death and inhibits tumor growth. Cancer Biol Ther 15, 8.
  2. Allen, J. E., Patel, A. S., Prabhu, V. V., Dicker, D. T., Sheehan, J. M., Glantz, M. J., and El-Deiry, W. S. (2014). COX-2 Drives Metastatic Breast Cells from Brain Lesions into the Cerebrospinal Fluid and Systemic Circulation. Cancer Res 74, 2385-2390.
  3. Ananda, G., Hile, S. E., Breski, A., Wang, Y., Kelkar, Y., Makova, K. D., and Eckert, K. A. (2014). Microsatellite Interruptions Stabilize Primate Genomes and Exist as Population-Specific Single Nucleotide Polymorphisms within Individual Human Genomes. PLoS Genet 10, e1004498. 
  4. Cai, Y., Xue, F., Fleming, C., Yang, J., Ding, C., Ma, Y., Liu, M., Zhang, H. G., Zheng, J., Xiong, N., and Yan, J. (2014). Differential developmental requirement and peripheral regulation for dermal Vgamma4 and Vgamma6T17 cells in health and inflammation. Nat Commun 5, 3986. 
  5. Chang, G. S., Chen, X. A., Park, B., Rhee, H. S., Li, P., Han, K. H., Mishra, T., Chan-Salis, K. Y., Li, Y., Hardison, R. C., Wang, Y. and Pugh, B.F. (2014). A Comprehensive and High-Resolution Genome-wide Response of p53 to Stress. Cell Rep 8, 514-527.
  6. England, M. R., Purdy, J. G., Ropson, I. J., Dalessio, P. M., and Craven, R. C. (2014). Potential role for CA-SP in nucleating retroviral capsid maturation. J Virol 9, 9.
  7. Fang, Z. Z., Krausz, K. W., Nagaoka, K., Tanaka, N., Gowda, K., Amin, S. G., Perdew, G. H., and Gonzalez, F. J. (2014). In vivo application of the pure aryl hydrocarbon receptor antagonist GNF-351 is limited to the gastrointestinal track. Br J Pharmacol 171, 1735-1746. 
  8. Luque, A., Collepardo-Guevara, R., Grigoryev, S., and Schlick, T. (2014). Dynamic condensation of linker histone C-terminal domain regulates chromatin structure. Nucleic Acids Res 42, 7553-7560. 
  9. Modesto, J. L., Hull, A., Angstadt, A. Y., Berg, A., Gallagher, C. J., Lazarus, P., and Muscat, J. E. (2014). NNK reduction pathway gene polymorphisms and risk of lung cancer. Mol Carcinog 29, 22187.
  10. Moran, J. R., and Short, P. F. (2014). Does Cancer Reduce Labor Market Entry? Evidence for Prime-Age Females. Med Care Res Rev 71, 224-242. 
  11. Pandey, M. K., Kale, V. P., Song, C., Sung, S. S., Sharma, A. K., Talamo, G., Dovat, S., and Amin, S. G. (2014). Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways. Exp Hematol 14, 261.
  12. Rye-McCurdy, T. D., Nadaraia-Hoke, S., Gudleski-O'Regan, N., Flanagan, J. M., Parent, L. J., and Musier-Forsyth, K. (2014). Mechanistic Differences Between Nucleic Acid Chaperone Activity of the Gag Proteins of Rous Sarcoma Virus and Human Immunodeficiency Virus Type 1 are Attributed to the MA Domain. J Virol 88, 7852-7861.