Basic Science and Engineering

Laboratory Evaluation of Hemolysis and Systemic Inflammatory Response in Neonatal Nonpulsatile and Pulsatile Extracorporeal Life Support Systems

The objective of this study is to compare the systemic inflammatory response and hemolytic characteristics of conventional roller pump and alternative diagonal pump with nonpulsatile and pulsatile mode in simulated neonatal extracorporeal life support (ECLS) systems.

In-vitro Hemodynamic Evaluation of Five 6 Fr and 8 Fr Arterial Cannulae in Simulated Neonatal CPB Circuits

The objective of this study is to evaluate five small-bore arterial cannulae (6 Fr and 8Fr) in terms of pressure drop and hemodynamic performance in simulated neonatal cardiopulmonary bypass (CPB) circuits.

Impact of Pulsatility and Flow Rates on Hemodynamic Energy Transmission in an Adult ECLS System

The objective of this study is to investigate the total hemodynamic energy and surplus hemodynamic energy transmission of a novel adult ECLS system with non-pulsatile and pulsatile settings and varying pulsatility. The study intends to provide insight into what level of pulsatility is the most effective setting in this ECLS system.

Evaluation of hemodynamic performance of a combined ECLS and CRRT circuit in seven positions with a simulated neonatal patient (Clinical/ Engineering)

Since it is common for patients treated with extracorporeal life support (ECLS) to subsequently require continuous renal replacement therapy (CRRT), and neonatal patients encounter limitations due to lack of access points, inclusion of CRRT in the ECLS circuit could provide advanced treatment for this population. The objective of this study is to evaluate an alternative neonatal extracorporeal life support (ECLS) circuit containing either a centrifugal pump or roller pump with one of seven configurations of CRRT using the Prismaflex 2000 System.

Evaluation of Neonatal/Pediatric/Adult Hollow-fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/ Multidisciplinary Approach (Clinical/ Engineering)

The objective of this study is to compare the hemodynamic performances and gaseous microemboli (GME) handling ability of several neonatal/pediatric/adult oxygenators in a simulated cardiopulmonary bypass (CPB) models and the importance of adding an arterial filter in the CPB circuits.

Building a Better Neonatal ECLS Circuit: Comparison of Hemodynamic Performance and Gaseous Microemboli Handling in Different Pump and Oxygenator Technologies (Clinical/ Engineering)

The objective of this study is to evaluate hemodynamic performance and GME handling using an alternative neonatal ECLS circuit with two different pumps and polymethylpentene oxygenators in addition to the Better-Bladder in a simulated neonatal ECLS system.

Neonatal/Pediatric/Adult Extracorporeal Life Support Systems with Pulsatile and Non-Pulsatile flow:  Research and Education at Penn State Children's Hospital (Clinical/ Engineering)

The main objective of this proposal is to educate and train clinicians, with next generation ECLS oxygenators and blood pumps.

Discovery Proteomics During Pediatric Cardiac Surgery (Clinical/ Basic Science)

These studies use state-of-the art two-dimensional gel electrophoresis, liquid chromatography, and mass spectrometry along with multi-analyte profile immunoassays to identify altered serum proteins resulting from CPB perfusion modes. In addition, these studies may lead to the identification of specific preclinical markers that are associated with short- and long-term outcomes that can be used to further optimize strategies for CPB in high-risk pediatric populations.

Microdevices for Measuring CPB Systemic Inflammation (Engineering/Basic Science)

This study is designed to develop a novel approach to measuring plasma cytokine and complement concentrations in real-time within a microfluidic analytical system during cardiopulmonary bypass procedures.

Microfluidic Dialysis Platforms for Monitoring Cardiopulmonary Bypass Systemic Inflammation (Engineering/Basic Science)

The objective of this study is to design microanalytical devices capable of continuously measuring antigen-substrate binding by employing microfabrication techniques and designing a microfluidic immunoassay platform that is able to measure concentrations of pro-inflammatory cytokines and complement in vitro.

International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion (Clinical/ Basic Science/ Engineering)

The main objective of this conference is to focus on the current problems associated with pediatric cardiac patients during and after acute or chronic cardiac support. In this conference, we bring together as many distinguished physicians and scientists as possible, in order to precisely define the current problems and to suggest solutions with novel approaches. During the past 12 events (2005-2016), over 3,000 participants from 34 countries appreciate 1,049 presentations along with over 435 peer-reviewed publications including original articles, editorials, special reports, letters and case reports.

International Conference website